Daniel V. Pratt's Vita<!wide>

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Daniel V. Pratt, Ph.D.
Assistant Professor of Chemistry

Office Phone: 641-784-5286
Email: pratt@graceland.edu
PROFESSIONAL EXPERIENCE:
  • Graceland College, Lamoni, Iowa fall 1999-present
    • Assistant Professor
      • Courses taught: Introduction to Chemistry, Introduction to Organic and BioChemistry Organic Chemistry, Qualitative Organic Analysis and Analytical Chemistry.
  • Saint Mary College, Leavenworth Kansas
    • Assistant Professor
      • Courses taught: General Chemistry, Organic Chemistry, Instrumental Analysis, Analytical Chemistry and Chemistry Seminar. Additional responsiblities have included work on the Alcohol Task Force, 2 search committees, a college management system on assessment, campus wide judicial board and student advising.
      • Faculty advisor to the science and math club
  • Kansas City Kansas Community College, Kansas City, Kansas, fall 1996-spring 1997
    • Adjunct Professor
      • Courses taught: Organic Chemistry, Organic laboratory, and Mortuary Chemistry
  • Donnelly College, Kansas City, Kansas fall 1996-spring 1997
    • Adjunct Professor
      • Courses taught: Introduction to Pharmacology, and General Chemistry I and II.
  • Rockhurst College, Kansas City, Missouri, fall 1996-spring 1997
    • Adjunct Professor
      • Courses taught: 4 lab sections and 2 study sessions
  • Longview Community College, Lee’s Summit, Missouri spring 1997 and 1998
    • Adjunct Professor
        Courses taught: Introduction to Chemistry and the corresponding laboratory.
  • PARK COLLEGE, Parkville, Missouri, Summer 1996 and 1997
    • Adjunct Professor
      • Courses taught: General Chemistry I and II, Instrumental Analysis.
      • Directed one assistant in the preparation and set-up of laboratory experiments.
  • OHMEDA PHARMACEUTICAL PRODUCTS DIVISION OF BOC GROUP, Murray Hill, NJ, October 1991-January 1995
    • Senior Scientist
      • Successfully designed and synthesized 2A selective adrenergic agonists based upon a heterocyclic backbone.
      • Synthesized and identified a structurally novel local anesthetic.
      • Utilized reverse and straight phase HPLC, MPLC and chromatotron for the purification of new products.
      • Utilized UV, IR, and NMR for identification of new products.
      • Directed the research of a masters level scientist (1991-1992).
  • UNIVERSITY OF KANSAS, Lawrence, KSJanuary, 1990-September 1991
    • Postdoctoral Research, under direction of Professor Robert P. Hanzlik Successfully performed the asymmetric synthesis of R and S13C and D2 labeled p-nitrostyreneoxide.
    • Developed a winning combination for the analysis of chiral compounds utilizing NMR chiral shift reagents and Mosher esters. Measured the kinetic isotope effects of labeled p-nitrostyreneoxide.
    • Conducted the isolation and purification of microsomal epoxide hydrase.
    • Determined the isotopic enrichment of labeled molecules by GC/MS.
    • Performed purification of labeled molecules with straight and reverse phase HPLC techniques.
  • IOWA STATE UNIVERSITY, Ames, IA, April 1988-December 1989 (Center for immune enhancement in domestic animals.)
    • Postdoctoral Research, under direction of Professor George A. Kraus
    • Developed a new method for the synthesis of quinone-containing polyaromatic HIV inhibitors.
    • Achieved the intramolecular cyclization of indole and pyrrolidine containing dienes in approaches to strychnine and lyngbyatoxin.
  • UNIVERSITY OF WASHINGTON, Seattle, WA, September 1981-March 1988
    • Doctoral Research, under direction of Professor Paul B. Hopkins
    • Successfully synthesized an advanced model for Betaenones and Stemphyloxin.Natural products with highly substituted trans-decalin ring systems with 8 chiral centers.
    • Developed and successfully implemented a practical large-scale oxidation of hydroquinones to benzoquinones.
    • Synthesized novel amino acids via intramolecular selenium rearrangements.
    • Doctoral Research, under direction of the late Professor Boris Weinstein Studied approaches to the synthesis of Scotophobin
Software experience:
  • Windows 2000, 98, 95 and 3.1.Adobe Acrobat, Frontpage, MacSpartan, Chem Draw, ISIS Draw, Reaccs, RS1, Excel, Powerpoint, Word and Word Perfect.Experienced in Macintosh and PC based systems.
EDUCATION:
  • Postdoctoral Fellow, Medicinal Chemistry, University of Kansas (1990-1991)
  • Postdoctoral Fellow, Organic Chemistry, Iowa State University, (1988-1989)
  • Ph.D., Organic Chemistry, University of Washington, (1988)
  • B.S., Chemistry, Graceland College, Lamoni, IA(1981)
MEMBERSHIPS:
  • American Chemical Society, Division of Organic Chemistry, Medicinal Chemistry, Analytical Chemistry, and Toxicology
PERSONAL:
  • Interests include skiing, cycling, running, baking, furniture refinishing, camp counseling and home remodeling.
Publications:
    1. "Synthesis of Protected Racemic , -Unsaturated--Amino Acids via -Phenylseleno-,-unsaturated Esters,"Fitzner, J.N.; Pratt, D.V. and Hopkins, P.B. Tetrahedron Lett. 1985, 26, 1959.
    2. "Allylic Selenides in Organic Synthesis:New Methods for the Synthesis of Allylic Amines," Shea, R.G; Fitzner, J.N.; Fankhauser, J.E.; Spaltenstein, A.; Carpino, P.A.; Peevey, R.M.; Pratt, D.V.; Tenge, B.J. and Hopkins, P.B. J. Org. Chem. 1986, 51, 5243.
    3. "Diastereocontrol of the Claisen Rearrangement by Substituents External to the Pericyclic Array:Synthetic Studies on Betaenone B and Stemphyloxin I," Pratt, D.V. and Hopkins, P.B. Tetrahedron Lett. 1987, 28, 3065.
    4. "Isolation and characterization of a Stable Simple Enol," Pratt, D.V. and Hopkins, P.B. J. Am. Chem. Soc., 1987, 109, 5553.
    5. "Practical Large-Scale Oxidation of 1,4-Hydroquinones to 1,4-Benzoquinones Using Hydrogen Peroxide/Catalytic Diphenyl Diselenide," Pratt, D.V.; Ruan, F. and Hopkins, P.B. J. Org. Chem. 1987, 52, 5053.
    6. "Anionic Oxy-Claisen Rearrangement of a Tricyclic -Alkoxy Ketone," Kirchner, J.; Pratt, D.V. and Hopkins, P.B. Tetrahedron Lett. 1988, 29, 4229.
    7. "Synthesis of (±)-De-4-(3'-Hydroxypropionyl)Betaenone B, an Advanced Model for Betaenones and Stemphyloxin I," Pratt, D.V. and Hopkins, P.B. J. Org. Chem., 1988, 53, 5885.
    8. "Antiretroviral Activity of Synthetic Hypericin and Related Analogs," Kraus, G.A.; Pratt, D.V.; Tossberg, J. and Carpenter, S. Biochemical and Biophysical Research Communications, 1990, 172, 149.
    9. "Synthesis and 2-Adrenergic Activities of Imidazole and Imidazolidine Analogues:In Vitro and In Vivo Selectivity," Bagley, J.; Brockunier, L.; Kudzma, L.; Pandit, C.R.; Pratt, D.; Galdes, A.; Jerussi, T.P.; Del Vecchio, R.A.; Harris, S. Med. Chem. Res., 1994, 4, 346.
Research Presentations:
    1. "Studies of the Claisen Rearrangement.Fortuitous Preparation of a Stable Simple Enol," Pratt, D.V. and Hopkins, P.B. Dept. of Chemistry, University of Washington, Presented at the 42nd Northwest Regional Meeting of the American Chemical Society, Western Washington University, Bellingham, WA, June 19, 1987.
    2. "Studies of the Claisen Rearrangement.Fortuitous Preparation of a Stable Simple Enol," Pratt, D.V. and Hopkins, P.B. Dept. of Chemistry, University of Washington, Presented at the 30th National Organic Chemistry Symposium of the American Chemical Society, University of British Columbia, Vancouver, Canada, June 23, 1987.
    3. "Approaches to the Synthesis of Indole Alkaloids," Pratt, D.V. and Kraus, G.A. Dept. of Chemistry, Iowa State University, presented at the joint Ames and Iowa Sections of the American Chemical Society, Grinnel College, Grinnell, Iowa, April 29, 1989.
    4. "Mechanistic Studies of Epoxide Hydrase," Pratt, D.V. and Hanzlik, R.P. Dept. of Medicinal Chemistry, University of Kansas, presented at the 4th Annual Wesley Cancer Symposium, Marriott Hotel, Wichita, Kansas, April 2, 1991.
    5. "Isotope Ratio Measurements by Whole Molecule MS: Comparison of a Quadropole and a Magnetic Instrument," Andrew, N.; Pratt, D.V.; Hanzlik, R.P. and Williams, T. Dept. of Medicinal Chemistry, University of Kansas, presented at the 39th ASMS Conference on Mass Spectrometry and Allied Topics, The Opryland Hotel, Nashville, Tennessee, May 19-24, 1991.
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